View R&D Systems research products for gp130. 0.1 - 8 ng/mL (Cell Culture Supernates), 0.3 - 16 ng/mL (Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)

Enrichment of STAT3 regulation and gp130-ligands in activated fibroblasts and macrophages led us to reason that gp130 blockade might rescue the activated program.

Immunol Today 1999  membranbundet signaleringskomplex (gp130) (Boeuf 1997). Eliminering av IL-6 familjen och MEF initierar en spontan okontrollerad differentiering av mESC in  076_1136_240_15_20200920170323 · GP130 Leaf Örhängen. kr238.40. Guldpälererade, Löv Örhängen. More details · < Previous · 1, 2, 3 · Next > · < Previous  Glycoprotein 130 (gp130), en signalundersökningsenhet delad av interleukin-6 (IL-6) -familjen av cytokinreceptorer, visades också ge betydande bidrag till  Reciprocal regulation of gastrointestinal homeostasis by SHP2 and. STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002; 8:1089-1097.

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Ohtani, T. et al. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12 , 95–105 (2000). CAS Article Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses, heart development, and fertility. Enrichment of STAT3 regulation and gp130-ligands in activated fibroblasts and macrophages led us to reason that gp130 blockade might rescue the activated program. One gp130 receptor cytokine in particular, ciliary neurotrophic factor (CNTF), a pluripotent neurocytokine, showed efficacy as a potential anti-obesogenic therapy.

2019-08-08 · This tool, leucine zipper plus gp130 (L-gp130), has the entire extracellular portion of gp130 replaced with the dimerizing human c-Jun leucine zipper sequence, thereby forcing gp130 dimerization, resulting in cell-autonomous and constitutive activation of associated intracellular signaling independent of cytokine stimulation .

GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. The cytokine receptor gp130 is the shared signalling subunit of the IL-6-type cytokines.

Glycoprotein 130 (Gp130) is a common receptor subunit of the interleukin-6 family of cytokines. The Gp130 receptor can be stimulated by leukemia inhibitor factor or cardiotrophin-1, leading to the activation of the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, ERK, and PI3K/Akt pathways.

GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. INTRODUCTION: Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes. gp130 is a receptor component for IL-6, IL-11, IL-27, and IL-31, as well as for several cytokines that are important in development. 6 Targeted disruptions of the gp130 gene are lethal in early embryogenesis. The mice exhibit defects in myocardial, hematologic, and placental development. GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3).

280,40 kr. LRC · 4 Juni 2012 · #5,308. Tja, eftersom den förra bilden gick så snabbt kan jag ta en till, som nog är lite svårare: gp130.jpg  Father: Claes Erik Andersson Born: 1848, Sweden Marr: 1876 Died: 1912. Mother: Karin Persdotter Born: 1854, Sweden Died: 1914, Sweden. Sven Elis Brodin 29Sanchez-Cuenca J, Martin JC, Pellicer A, Simon C: Cytokine pleiotropy and redundancy--gp130 cytokines in human implantation. Immunol Today 1999  membranbundet signaleringskomplex (gp130) (Boeuf 1997).
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Abbildung 27: Ausbleibende Müllerzellaktivierung in gp130 PPT - Hirnnerven-Läsionen N. I, N. II  Effekt av anti-gp130-antikropp på överlevnaden av CVB3-infekterade möss med CVB3 med anti-gp130-antikroppsbehandling i början av akut myokardit. Signaltransduktionen av gp130 involverar JAKs JAK1, JAK2 och TyK2, och därefter innefattar nedströms effektorerna de STAT3- och mitogenaktiverade  Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family.

(D1) followed by a CBM (D2. Background & aims: Interleukin 6 (IL-6) contributes via its signal transducer gp130 to the acute phase response (APR) in hepatocytes. Recent studies indicated  30 Jun 2020 gp130 is a potential therapeutic target to improve heart regeneration after cardiac injury. Clinical Perspective.
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Deletion of gp130 in hematopoietic cells increases susceptibility to sepsis‐induced damage, inflammation, and mortality. A) Decreased survival in mice with gp130 deletion in bone marrow cells (BMC‐KO, compared with BMC‐WT) or in myeloid cells [LysCre positive (LysCre +), compared with LysCre negative (LysCre −)] after polymicrobial sepsis induced by CLP.

Diseases associated with IL6ST include Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive and Stuve-Wiedemann Syndrome.Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Physiological and Pathological Hypertrophy of the Heart.